Altered fractionation outcomes for hypoxic head and neck cancer using theHYP-RTMonte Carlo model
نویسندگان
چکیده
منابع مشابه
Altered fractionation for head and neck cancer.
A conventional course of radiation for squamous cell carcinoma in the United States is generally 70 Gy in 7 weeks, with a once-daily dose of 1.8 to 2 Gy. This schedule has a modest success rate in curing head and neck cancer. The past several decades have seen numerous investigations into altering this schedule to optimize the results of radiation. Two approaches, founded on radiobiologic princ...
متن کاملAltered Fractionation for Head and Neck Cancer
Delivery of therapeutic radiation in multiple sessions, or fractions, has been practiced since the discovery of radiation’s potential to cure malignancies. Initially, this was done out of practical necessity: Radiation was delivered at a low dose rate, and the treatment sessions had to be repeated to obtain the desired effect. Technologic improvements eventually allowed for treatments in one se...
متن کاملHead and neck cancer: altered fractionation schedules.
Local control is paramount in the treatment of localized advanced head and neck cancer. Standard radiotherapy cures a high percentage of early tumors--more than 80% of the early laryngeal tumors--but fewer of the advanced tumors. Attempts have therefore been made to improve the therapeutic ratio by: A) hyperfractionation: reducing the dose per fraction to reduce late morbidity; the total dose i...
متن کاملRole of Altered Fractionation & Chemoradiation in Head and Neck Cancer
Dividing a dose into a number of fractions spares normal tissues because of repair of SLD between dose fractions and repopulation of cells if the overall time is sufficiently long. At the same time dividing a dose into a number of fractions increases the damage to the tumor because of reoxygenation and reassortment of cells into radiosensitive phases of the cell cycles between dose fractions. T...
متن کاملEfficient Monte Carlo modelling of individual tumour cell propagation for hypoxic head and neck cancer.
A Monte Carlo tumour model has been developed to simulate tumour cell propagation for head and neck squamous cell carcinoma. The model aims to eventually provide a radiobiological tool for radiation oncology clinicians to plan patient treatment schedules based on properties of the individual tumour. The inclusion of an oxygen distribution amongst the tumour cells enables the model to incorporat...
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ژورنال
عنوان ژورنال: The British Journal of Radiology
سال: 2013
ISSN: 0007-1285,1748-880X
DOI: 10.1259/bjr.20120443